Colorectal carcinoma: Evaluation of systemic values of interleukin-1 and interleukin-33 in patients with and without thrombocytosis

Background/Aim. Reactive thrombocytosis, as a paraneoplastic syndrome, is often observed in cancer patients. A variety of tumor-related humoral factors and cytokines con-tribute to tumor-stimulated thrombopoiesis. However, the exact role these pathogenesis thrombocytosis remains unclear. The aim this study was analyze systemic values clinical-pathological characteristics colorectal carcinoma (CRC) patients with without thrombocytosis. Methods. Fifty nine CRC were involved divided into two groups according number platelets. We recorded analyzed data about: age, gender, size cancer, localization, metastasis, vascular or lymph vessel invasion, nuclear grade, histological differentiation rate, tumor, nodus, metastasis (TNM) stage concentration [interleukin (IL)-1, IL-33, IL-12, IL-17 interferon (IFN)-?] both groups. Results. had significantly higher grade (p = 0.002); percentage detectable metastatic lesions liver 0.002), lung 0.001), peritoneal carcinomatosis invasion blood 0.012) vessels 0.010). Concentrations tumor markers [alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) 19-9 (CA19-9)] se-rum IL-1 nd I L-33 IL-1/IL-12 0.016), IL-1/IFN-? 0.007), IL-1/IL-17 0.006), IL-33/IL- 12 IL-33/IFN-? IL-33/IL-17 IL-33/IL-1 0.006) ratios comparison Analysis Receiver Operating Characteristic (ROC) curves showed that [area under curve (AUC) 0.718; 95% confidence interval (CI): 0.567?0.868; sensitivity 69.2%, specificity 62.9%] IL-33 (AUC 0.763; CI: 0.614? 0.911; 84.6%, 65.7%)], could be serve possible for Conclusion. correlated high thrombocyte more aggressive CRC.